Chez Charles/ tags/ pages tagged splicing
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The human genome contains over a million autonomous exons.
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Where the minor things are: a pan-eukaryotic survey suggests neutral processes may explain much of minor intron evolution.
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Animal, Fungi, and Plant Genome Sequences Harbor Different Non-Canonical Splice Sites.
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Evolution of spliceosomal snRNA genes in metazoan animals.
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Splicing heterogeneity: separating signal from noise.
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Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.
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A highly conserved program of neuronal microexons is misregulated in autistic brains.
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Regulation of alternative splicing at the single-cell level.
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Determining exon connectivity in complex mRNAs by nanopore sequencing.
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Human tRNA synthetase catalytic nulls with diverse functions.
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U1 snRNP determines mRNA length and regulates isoform expression.
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Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAs.
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Lariat sequencing in a unicellular yeast identifies regulated alternative splicing of exons that are evolutionarily conserved with humans.
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Transcriptome analysis of human tissues and cell lines reveals one dominant transcript per gene.
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Promoter directionality is controlled by U1 snRNP and polyadenylation signals.
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Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells.
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Differential analysis of gene regulation at transcript resolution with RNA-seq.
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Alternative isoform regulation in human tissue transcriptomes.
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Alternative splicing produces high levels of noncoding isoforms of bHLH transcription factors during development.
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