Locked Nucleic Acids

LNA bases have been reported by some to improve the efficiencly of template switching, but it has been challenged by others.

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A cost effective 5' selective single cell transcriptome profiling approach with improved UMI design.
Posted Mon Dec 26 05:40:17 2016

Locked nucleic acid pentamers as universal PCR primers for genomic DNA amplification.
Posted Mon Aug 29 07:09:13 2016

Comparison of RNA- or LNA-hybrid oligonucleotides in template-switching reactions for high-speed sequencing library preparation.
Posted Mon Oct 7 01:07:21 2013

Smart-seq2 for sensitive full-length transcriptome profiling in single cells.
Posted Wed Sep 25 07:35:28 2013

Reduction of non-insert sequence reads by dimer eliminator LNA oligonucleotide for small RNA deep sequencing.
Posted Sun Jan 9 15:08:12 2011