Cheng L, Zhao S, Li T, Hou S, Luo Z, Xu J, Yu W, Jiang S, Monti M, Schindler D, Zhang W, Hou C, Ma Y, Cai Y, Boeke JD, Dai J.

Nat Commun. 2024 Jan 26;15(1):770. doi:10.1038/s41467-023-44511-5

Large-scale genomic rearrangements boost SCRaMbLE in Saccharomyces cerevisiae.

“SparLox83R, a yeast strain containing 83 loxPsym sites distributed across all 16 chromosomes” “LOH and aneuploidy are frequently detected in SCRaMbLEd heterozygous diploids” “the proportion of rearrangement events was 10-fold higher in haploid than in diploid cells.”