Hu Q, Yu H, Ye L.

Biotechnol Bioeng. 2022 Jul 26. doi:10.1002/bit.28192

Production of retinoic acid by engineered Saccharomyces cerevisiae using an endogenous aldehyde dehydrogenase.

Screen for the most efficient aldehyde dehydrogenases to produce retinoic acid in S. cerevisiae strain Y03 identified MmAldh, which was used to scan the yeast genome for an endogenous replacement. Hfd1 was found, and increasing its copy number lead to the best yields.