Genetic and spatial organization of the unusual chromosomes of the dinoflagellate Symbiodinium microadriaticum.

Nand A, Zhan Y, Salazar OR, Aranda M, Voolstra CR, Dekker J.

Nat Genet. 2021 May;53(5):618-629. doi: 10.1038/s41588-021-00841-y

“We find two chromosome-scale patterns of GC content fluctuations: (1) GC content increases towards the ends of the chromosomes and (2) GC content dips to form small local minima at Hi-C domain boundaries.” “most domain boundaries observed by Hi-C are located at positions where transcription of blocks of unidirectional genes converges.” “chromatin conformation is sensitive to treatment of cells with triptolide and DRB.”