Nucleic Acids Res. 2020 Jul 3:gkaa563. doi:10.1093/nar/gkaa563

Wragg JW, Roos L, Vucenovic D, Cvetesic N, Lenhard B, Müller F.

Embryonic tissue differentiation is characterized by transitions in cell cycle dynamic- associated core promoter regulation.

“TATA-box enrichment in genes upregulated in G1 (∼30 bp upstream of the TSS), but no enrichment in WW dinucleotide frequency between the G1 and S/G2/M differentially expressed gene sets.” “Four TATA-divergent poly-W pentamers (TTAAA, TAAAT, TTTAA, AATAA) were significantly enriched (P < 0.001–0.01) in the promoters of genes upregulated in S/G2/M cells.” “TATA-box utilization is highly enriched in sharp promoters over other behaviours, interestingly however this is only true in the gene set upregulated in G1. In the S/G2/M upregulated gene set promoter shape was only weakly associated with TATA utilization.”