Nepal C, Hadzhiev Y, Balwierz P, Tarifeño-Saldivia E, Cardenas R, Wragg JW, Suzuki AM, Carninci P, Peers B, Lenhard B, Andersen JB, Müller F.

Nat Commun. 2020 Jan 10;11(1):168. doi:10.1038/s41467-019-13687-0

Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing.

In zebrafish, human and drosophila, the majority promoters containing a YC (5′-TOP) TSS motif also carry a YR (PyPu) TSS motif. In dual YC/YR promoters expression of the two TSS types can be coordinated, but profiling at the zebrafish maternal-zygotic transition also shows cases where they are regulated independently. The expression of snoRNAs was better correlated with YC-initiation than with YR-initiation.