Coley CW, Thomas DA 3rd, Lummiss JAM, Jaworski JN, Breen CP, Schultz V, Hart T, Fishman JS, Rogers L, Gao H, Hicklin RW, Plehiers PP, Byington J, Piotti JS, Green WH, Hart AJ, Jamison TF, Jensen KF.

Science. 2019 Aug 9;365(6453):eaax1566. doi:10.1126/science.aax1566

A robotic platform for flow synthesis of organic compounds informed by AI planning.

An algorithm proposes a synthetic route for a robotic flow chemistry platform, an expect makes practical amendments for safety or efficiency, and the robot assembles the flow platform and runs the synthesis. Practical challenges remain, such as predicting solubility of the products to avoid clogging the pipes with precipitates.