Mikhail Kolmogorov, Jeffrey Yuan, Yu Lin, Pavel Pevzner

Nat Biotechnol. 2019 May;37(5):540-546. doi:10.1038/s41587-019-0072-8

Assembly of Long Error-Prone Reads Using Repeat Graphs

“Flye constructs (overlapping) contigs with possible assembly errors at the initial stage, combines them into an accurate assembly graph, resolves repeats in the assembly graph using small variations between various repeat instances that were left unresolved during the initial assembly stage, constructs a new, less tangled assembly graph based on resolved repeats, and finally outputs accurate contigs as paths in this graph.”