Proc Natl Acad Sci U S A. 2018 May 14. pii: 201801040. doi:10.1073/pnas.1801040115

Sharp NP, Sandell L, James CG, Otto SP.

The genome-wide rate and spectrum of spontaneous mutations differ between haploid and diploid yeast.

16 generations per day for 100 days in 220 cell lines yielded 2,000 mutations, with more single-nuceotide mutations in haploids and more copy number variations in diploids.