Nucleic Acids Res. 2017 Sep 6;45(15):9046-9058. doi:10.1093/nar/gkx633

Agudo R, Calvo PA, Martínez-Jiménez MI, Blanco L.

Engineering human PrimPol into an efficient RNA-dependent-DNA primase/polymerase.

“PrimPol as a DNA primer maker during reverse transcription, mutant Y89R HsPrimPol rendered up to 17-fold more DNA than with random hexamer primers.”