Payen C, Fischer G, Marck C, Proux C, Sherman DJ, Coppée JY, Johnston M, Dujon B, Neuvéglise C.

Genome Res. 2009 Oct;19(10):1710-21. doi:10.1101/gr.090605.108

Unusual composition of a yeast chromosome arm is associated with its delayed replication.

“high GC content (52.9%) of the 1-Mb left arm of chromosome C (abbreviated here as ‘C-left’)” “The replication timing of C-left is delayed compared with the rest of the genome” “The global gene density, transcriptional orientations, proportion of orthologs to S. cerevisiae essential genes, and proportion of genes in families are comparable between C-left and the rest of the genome. The only differences are modest: the complete absence of any traces of LTR retrotransposons, an overrepresentation of microsatellites, and a moderate increase in CDS length.”