Marteijn RC, Jurrius O, Dhont J, de Gooijer CD, Tramper J, Martens DE.

Biotechnol Bioeng. 2003 Feb 5;81(3):269-78. doi:10.1002/bit.10465

Optimization of a feed medium for fed-batch culture of insect cells using a genetic algorithm

11 parameters encoded in 5 bits each. 4 generations of 20 experiments each. Helicoverpa zea cell-line HzAm1.