Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):596-601 doi:10.1073/pnas.012372799

Hogrefe HH, Hansen CJ, Scott BR, Nielson KB.

Archaeal dUTPase enhances PCR amplifications with archaeal DNA polymerases by preventing dUTP incorporation.

dTTP is deaminated to dUTP during PCR, which causes the synthesis of uracil-containing DNA, a potent inhibitor of archeal DNA polymerases.