Chez Charles/ biblio/ Protection of megabase DNA from shearing. Edit RecentChanges History Preferences Branchable Nucleic Acids Res. 1995 Oct 11;23(19):3999-4000. Kovacic RT1, Comai L, Bendich AJ Protection of megabase DNA from shearing. HCC protects DNA and enhances ligation at 1 mM. HCC is thought to condense DNA, similarly to spermine and spermidine.