Nat Genet. 2025 Jun;57(6):1524-1534. doi: 10.1038/s41588-025-02202-5

Phan MHQ, Zehnder T, Puntieri F, Magg A, Majchrzycka B, Antonović M, Wieler H, Lo BW, Baranasic D, Lenhard B, Müller F, Vingron M, Ibrahim DM.

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances.

“Interspecies point projection (IPP) [is] a synteny-based algorithm designed to map corresponding genomic locations in highly diverged genomes”. “We term [...] sequence-diverged orthologs ‘indirectly conserved’ (IC)”