D'Iorio M, Dewar K.

Life Sci Alliance. 2022 Oct 19;6(1):e202201434. doi:10.26508/lsa.202201434

Replication-associated inversions are the dominant form of bacterial chromosome structural variation.

“We assessed a total of 313 species that were represented by 10 or more complete genome sequences” “A genoform in this work refers to a group of collinear chromosomal sequences within a species with at least 80% sequence similarity and without an inversion spanning more than 50 Kb.” “In Gammaproteobacteria, the species Haemophilus influenzae, Haemophilus parainfluenzae, and Mannheimia haemolytica all contained inversions that were predominantly located away from the replication origin. We also observed species that were consistently offset from symmetry in one direction such as in B. pertussis”