Chez Charles/ biblio/ Caenorhabditis elegans DSB-3 reveals conservation and divergence among protein complexes promoting meiotic double-strand breaks.

Hinman AW, Yeh HY, Roelens B, Yamaya K, Woglar A, Bourbon HG, Chi P, Villeneuve AM.

Proc Natl Acad Sci U S A. 2021 Aug 17;118(33):e2109306118. doi:10.1073/pnas.2109306118

_Caenorhabditis elegans+ DSB-3 reveals conservation and divergence among protein complexes promoting meiotic double-strand breaks.

DSB-3, likely homologue of Mei4, interacts with DSB-1 and DSB-2 (likely homologues of Rec114). Together, they are interdependent for localisation to meiotic nuclei and promoting formation of crossovers. Yeast two-hybrid experiments that DSB-3 binds SPO-11 via DSB-1.