Waldvogel AM, Pfenninger M.

Genome Res. 2021 Sep;31(9):1582-1589. doi:10.1101/gr.275168.120

Temperature dependence of spontaneous mutation rates.

Study on the non-biting midge Chironomus riparius (harlequin fly). “short-term mutation accumulation experiments at temperatures between 12°C and 26°C.” “mutation rates depended on temperature in a U-shaped manner with increasing rates toward both temperature extremes.” Cold could increase mutation rates by eithery increasing oxydative stress or increasing generation time.