Calatayud S, Garcia-Risco M, Palacios Ò, Capdevila M, Cañestro C, Albalat R.

Mol Biol Evol. 2021 Jun 19:msab184. doi:10.1093/molbev/msab184

Tunicates illuminate the enigmatic evolution of chordate metallothioneins by gene gains and losses, independent modular expansions and functional convergences.

Ancestral two-domain organisation found in Cephalochordates and Vertebrates. Ascidians appear to have lost one domain and larvaceans proteins ressemble no other.