Elimination of rNMPs from mitochondrial DNA has no effect on its stability.

Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14306-14313

Wanrooij PH, Tran P, Thompson LJ, Carvalho G, Sharma S, Kreisel K, Navarrete C, Feldberg AL, Watt DL, Nilsson AK, Engqvist MKM, Clausen AR, Chabes A.

In mouse, mitochondrial DNA strands have a few (usually ~10 or less) ribonucleotides misincorporated into them. Their number correlate with the ration between rNTPs and dNTPs. Reducing misincorporation did not have obvious benefits for the animals.