Nat Methods. 2020 Mar;17(3):319-327. doi:10.1038/s41592-019-0730-2

Shipony Z, Marinov GK, Swaffer MP, Sinnott-Armstrong NA, Skotheim JM, Kundaje A, Greenleaf WJ.

Long-range single-molecule mapping of chromatin accessibility in eukaryotes.

Single-molecule long-read accessible chromatin mapping sequencing assay (SMAC-seq). Methylation of accessible chromatin with the EcoGII N6-methyladenosine (m6A) methyltransferase, followed by Nanopore sequencing. Specific improvements compared to other methods: single-strand resolution (on DNA wrapped to nucleosomes for instance), and chromatin coaccessibility patterns.