Zhou BR, Yadav KNS, Borgnia M, Hong J, Cao B, Olins AL, Olins DE, Bai Y, Zhang P.

Nat Commun. 2019 May 24;10(1):2301. doi:10.1038/s41467-019-10247-4

Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment.

Development of a single-chain antibody to stabilise nucleosomes and make them easier to image with cryo-EM. Beautiful pictures of the centromeric nucleosome bound to centromeric DNA; structural insights explaining why linker histones have low affinity for centromeric chromatin.