Proc Natl Acad Sci U S A. 2018 Jul 30. pii: 201806614. doi:10.1073/pnas.1806614115

Lynagh T, Mikhaleva Y, Colding JM, Glover JC, Pless SA.

Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes.

O. dioica, like other deuterostomes, has acid-sensing ion channels (ASICs). They are expressed in the nervous system.