Han KH, Arlian BM, Macauley MS, Paulson JC, Lerner RA.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E372-E381. doi:10.1073/pnas.1719259115

Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid β.

A library of single-chain antibodies was transfected in bone-marrow cells, which were translated in mice. The cells that migrated in the brain were enriched for a synthetic gene expressing an #antibody that binds Vimentin and causes it to be phosphorylated.