Liu N, Lee CH, Swigut T, Grow E, Gu B, Bassik M, Wysocka J.

Nature. 2017 Dec 6. doi:10.1038/nature25179

Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators.

A CRISPR-Cas9 screen identifies several chromatin regulators (such as the human silencing hub (HUSH) complex subunits MPP8 and TASOR, or MORC2) that repress the expression of L1 elements and their host genes.