Erwin GS, Grieshop MP, Ali A, Qi J, Lawlor M, Kumar D, Ahmad I, McNally A, Teider N, Worringer K, Sivasankaran R, Syed DN, Eguchi A, Ashraf M, Jeffery J, Xu M, Park PMC, Mukhtar H, Srivastava AK, Faruq M, Bradner JE, Ansari AZ.

Science. 2017 Nov 30. pii: eaan6414. doi:10.1126/science.aan6414

Synthetic transcription elongation factors license transcription across repressive chromatin.

Syn-TEFs. A BET inhibitor drug (JQ1) linked to a pyrrole- and imidazole-based polyamide targetting the motif AAGAAGAAG rescues Frataxin (FXN) in patient cells by promoting transcript elongation to paused polymerases.