Stadler MR, Haines JE, Eisen MB.

Elife. 2017 Nov 17;6. pii: e29550. doi:10.7554/eLife.29550

Convergence of topological domain boundaries, insulators, and polytene interbands revealed by high-resolution mapping of chromatin contacts in the early Drosophila melanogaster embryo.

High-resolution Hi-C analysis of Drosophila chromosomes in Rabl conformation during embryogenesis. “We propose a model in which insulators achieve domain separation by lowering the compaction ratio of bound chromatin, thereby converting the short lengths of insulator DNA (measured in base pairs) into large relative physical distances.”