Science. 2017 May 5;356(6337):539-542. doi:10.1126/science.aah5238

Sohail M, Vakhrusheva OA, Sul JH, Pulit SL, Francioli LC; Genome of the Netherlands Consortium; Alzheimer’s Disease Neuroimaging Initiative, van den Berg LH, Veldink JH, de Bakker PIW, Bazykin GA, Kondrashov AS, Sunyaev SR.

Negative selection in humans and fruit flies involves synergistic epistasis.

'Deleterious LOF mutations are further away from each other in the genome than expected by chance.