MBio. 2016 Sep 13;7(5). pii: e01446-16. doi:10.1128/mBio.01446-16

Dooley KE, Warburton A, McBride AA.

Tandemly Integrated HPV16 Can Form a Brd4-Dependent Super-Enhancer-Like Element That Drives Transcription of Viral Oncogenes.

‘Targeted disruption of factors binding to this element decreases viral transcription and causes cell death. ’