Devarkar SC, Wang C, Miller MT, Ramanathan A, Jiang F, Khan AG, Patel SS, Marcotrigiano J.

Proc Natl Acad Sci U S A. 2016 Jan 5. pii: 201515152 doi:10.1073/pnas.1515152113

Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.

5′ppp and Cap-0, but not Cap-1 dsRNA bind RIG-I and activate signalling.