Matteo Cossu, Violette Da Cunha, Claire Toffano-Nioche, Patrick Forterre, Jacques Oberto

Biochimie. 2015 Nov;118:313-21. doi:10.1016/j.biochi.2015.07.008

Comparative genomics reveals conserved positioning of essential genomic clusters in highly rearranged Thermococcales chromosomes

“The comparative genomics analysis presented here confirms the initial observation that Thermococcales chromosomes are highly rearranged. In these genomes, DNA sequence scrambling has reached such a high level that commonly observed prokaryotic chromosomal landmarks such as oriC and terC are no longer readily identifiable by measuring DNA composition biases.”