Nat Methods. 2015 Mar;12(3):251-7. doi: 10.1038/nmeth.3259

Koh KD, Balachander S, Hesselberth JR, Storici F.

Ribose-seq: global mapping of ribonucleotides embedded in genomic DNA.

Ligation with Arabidopsis tRNA ligase (AtRNL), that favors self-ligation in circular products, that are enriched by digesting linear molecules. rNMP incorporation frequency may be inversely related to dNTP concentration. More rNMP is incorporated on leading strands.