Vantaggiato C, Tocchetti M, Cappelletti V, Gurtner A, Villa A, Daidone MG, Piaggio G, Maggi A, Ciana P.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9561-6. doi:10.1073/pnas.1321750111

Cell cycle dependent oscillatory expression of estrogen receptor-α links Pol II elongation to neoplastic transformation.

c-MYB binding in intron 1 of ERα unblocks elongation during late S / G2 phase. The binding region is polymorphic and some variants are associated with cancer risks.