PLoS One. 2012;7(7):e40172. doi:10.1371/journal.pone.0040172

Hosp J, Sagane Y, Danks G, Thompson EM.

The evolving proteome of a complex extracellular matrix, the Oikopleura house.

“Almost half of the oikosin complement exhibit no known domain structures or other similarities to known proteins, suggesting de novo appearance in the appendicularian lineage. Known domains are implicated in cellulose binding, protein-protein interactions or sPLA2 activity. Production of the latter is concentrated in epithelial regions associated with construction of the fcf, suggesting a possible role of this structure in innate immune defence.” “The genomic organization of oikosin loci appears incompatible with common enhancers or locus control regions exerting [...] a coordinate regulatory role.”