Nature. 2012 Apr 11;485(7398):376-80. doi:10.1038/nature11082

Dixon JR, Selvaraj S, Yue F, Kim A, Li Y, Shen Y, Hu M, Liu JS, Ren B.

Topological domains in mammalian genomes identified by analysis of chromatin interactions.

A directionality index (DI), to detect topolgically associated domains, is described in the supplemental material. Bin size: 40 kbp, max distance: 2 Mbp.