Ranz JM, Maurin D, Chan YS, von Grotthuss M, Hillier LW, Roote J, Ashburner M, Bergman CM.

PLoS Biol. 2007 Jun;5(6):e152. doi:10.1371/journal.pbio.0050152

Principles of genome evolution in the Drosophila melanogaster species group.

“the breakpoint regions of 59% of the inversions (17/29) are associated with inverted duplications of genes or other nonrepetitive sequences” “We propose that the presence of inverted duplications associated with inversion breakpoint regions is the result of staggered breaks, either isochromatid or chromatid, and that this, rather than ectopic exchange between inverted repetitive sequences, is the prevalent mechanism for the generation of inversions in the melanogaster species group” “The overall rate of breakage in the D. melanogaster / D. yakuba lineage is 0.0183/Mb/Myr.”