Nat Methods. 2006 Jul;3(7):551-9 doi:10.1038/nmeth898

Diehl F, Li M, He Y, Kinzler KW, Vogelstein B, Dressman D

BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions.

Recommends (in Box 1) a double-biotin to avoid breaking the complexes at high temperatures.