Housworth EA, Postlethwait J

Genetics. 2002 Sep;162(1):441-8. doi:10.1093/genetics/162.1.441

Measures of synteny conservation between species pairs.

Introduces a syntenic correlation measure, ρ, which is a scaled chi-square statistic, and an alternative measure λ with measures “the proportion of errors made in assigning a gene to a chromosome in one species that can be eliminated by knowing which chromosome the orthologue belongs to in the other species.”

“We introduce a measure of genomic conservation, which we call syntenic correlation, which corresponds to a measure of how far the orthologues are from being independently scattered in the genomes of the two species. This measure is standardized to be between zero, for completely randomized arrangements of orthologues between the genomes, and one, for two genomes with perfect synteny conservation. Further, this measure can be used to compare genomic distances (i.e., Oxford grids) between many pairs of species.”