Zivanovic Y, Lopez P, Philippe H, Forterre P.

Nucleic Acids Res. 2002 May 1;30(9):1902-10. doi:10.1093/nar/30.9.1902

Pyrococcus genome comparison evidences chromosome shuffling-driven evolution.

“the extent of rearrangement that occurred after the three species diverged is much lower between P. abyssi and P. horikoshii than between these two species and P. furiosus.” “[In P. furiosus, the distribution of IS elements] is clearly non-random, since 16 of them are located near shuffled segments boundaries, five are in completely scrambled regions and only two are found within an undisturbed segment.” “the AT3 skew was less upset than the word skew (here GGTT), which was itself, as expected, less perturbed than the gene orientation skew”. Coding genes were weakly colinear with the replication direction in P. abissi and P. horikoshii, especially for highly expressed genes, but this correlation was less evident or absent for P. furiosus_.