Tillier ER, Collins RA

Nat Genet. 2000 Oct;26(2):195-7. doi:10.1038/79918

Genome rearrangement by replication-directed translocation.

X-shaped patterns in whole-genome comparisons dot plots. “Single-gene inversions occurred at 12 of 44 boundaries [of repositioned blocks of genes] identified in Chlamydia, compared with only 13 local inversions adjacent to any of the 643 genes not at a boundary” Proposes that origin-centered inversions caused by replication forks can generate the patterns.