Shen XX, Opulente DA, Kominek J, Zhou X, Steenwyk JL, Buh KV, Haase MAB, Wisecaver JH, Wang M, Doering DT, Boudouris JT, Schneider RM, Langdon QK, Ohkuma M, Endoh R, Takashima M, Manabe RI, Čadež N, Libkind D, Rosa CA, DeVirgilio J, Hulfachor AB, Groenewald M, Kurtzman CP, Hittinger CT, Rokas A.

Cell. 2018 Nov 29;175(6):1533-1545.e20. doi:10.1016/j.cell.2018.10.023

Tempo and Mode of Genome Evolution in the Budding Yeast Subphylum.

Survey of 45 metabolic traits over 400 million years of yeast evolutionary history suggests that lineages evolved by gene loss from a generalist ancestor. “We estimate the origin of the subphylum between 317 and 523 (95% credibility interval; posterior mean date: 404) million years ago (mya); the origin of the CUG-Ser1 clade, which contains the major opportunistic pathogen C. albicans, between 178 and 248 (210) mya, the origin of the whole-genome duplication (WGD) clade between 82 and 105 (93) mya, and the divergence of S. cerevisiae and C. albicans from their sister species (Saccharomyces paradoxus and Candida dubliniensis) between 4.0 and 5.8 (4.9) mya and 5.0 and 14.0 (8.7) mya, respectively”